“Why Me?”: What Causes Migraine

Headache and Migraine Basics | 3 Min. Read
Author: Care Tuner Migraine Team
Reviewed by: Ctrl M Health Medical Directors


  • Genetics, gender, and environmental changes are all risk factors for migraine, probably working in combination.
  • Migraine runs strongly in families. Having a first-degree relative with migraine increases your risk factor.
  • Being female is a major risk factor. In adulthood, three times as many women have migraine than men. 85 percent of people with chronic migraine are female.
  • Once you are predisposed to migraine, changes to your external or internal environment can trigger a migraine episode.

Full Article

All brains are complicated, but if you have migraine, yours is unique. That’s not mere flattery! Your brain is wired in such a way that it’s more susceptible to stimulation than other people’s brains. What causes migraine disease in the first place is likely a combination of a few key risk factors: genes, gender and environmental factors.

Are Migraines Genetic?

You have your father’s eyes, your grandma’s smile – and, unfortunately, your mom’s headaches. Heredity plays a strong part in predisposition to migraine, although so far, the exact mechanism is unclear. One rare form of migraine (hemiplegic migraine) was traced back to a single genetic mutation, but the predisposition to “common” migraines is the complex result of the interactions of perhaps 40 different genes.

When doctors ask patients for their family history, however, the genetic component becomes obvious:

    • 90 percent of people with migraine have a family history of migraine.
    • If you have a first-degree relative (mother, father, sibling) who has migraine without aura, you have 1.9 times increased risk of having migraine without aura, and 1.4 times increased risk of migraine with aura.
    • If you have a first-degree relative who has migraine with aura, your risk of having migraine with aura increases by a factor of 4.
    • Depression in your family is also a migraine risk factor. Migraine, anxiety and depression are often present together and are believed to share genes. 

Are Women More Prone to Migraines?

Migraine is a predominantly female disorder. That very fact is, sadly, a reason why migraine has not always been taken seriously, but instead shrugged off as an imaginary “women’s complaint.” However, it seems clear that having an adult female body is a major risk factor for migraine predisposition. Consider this:

    • Before puberty, both boys and girls have similar incidence of migraine.
    • In adulthood, three times as many women have migraine than men.
    • 85 percent of people with chronic migraine (at least 15 headache days per month) are female. 
    • Biological males who transition to female with sex hormones develop more migraine.
    • Possible explanations for women’s susceptibility point to the effect of sex hormones, as well as their fluctuations (such as during menstruation, pregnancy, and menopause).

Environmental Factors

Once you’re predisposed to migraine due to your DNA and/or gender, you’re extra-sensitive to certain environmental stimuli, which are what seem to tip you over into an actual migraine episode. These changes to our internal or external environment can include weather, stress, and a shift in hormones. We often call these factors “triggers.”

Other environmental factors can modify your genetic tendency to migraine. Early childhood psychological trauma or a past history of concussion may predispose you to more severe migraine, for example. 

There’s much that science doesn’t yet know. But one clear conclusion emerges from the picture thus far: You are not at fault for your migraine; what causes migraine are factors that were always beyond your control. So if you’re tempted to get caught up in the self-blame game, even for a moment, remember that your body was made this way. You’re complex and sensitive, all the way down to your genome — and you are not alone.

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